Seminars on pathological characterization and target therapy of solid tumors

3rd year - 2 Credits

Learning Objectives

At the end of the course, PhD students will have acquired knowledge on rare neoplasms of the breast, head and neck area and CNS, integrating the anatomical-clinical aspects with the molecular aspects important for therapeutic targeting. Moreover the course will provide an integrated understanding of the mechanisms of action of targeted therapies directed at tyrosine kinase membrane receptors. Additionally, the course will explore and investigate the primary mechanisms of resistance to these therapies, offering insights into the challenges and advancements in overcoming treatment resistance. Through a combination of theoretical knowledge and case studies, students will gain a comprehensive perspective on how these therapies function at the molecular level and the factors that can limit their efficacy in clinical settings.

Module 1 - Professor Maria Pia Foschini

Course Contents

-Clinical/pathological aspects of breast neoplasms
-Clinical/pathological aspects of head and neck squamous cell carcinoma
-Clinical/pathological aspects of glioma
-Applications of long read sequencing in neurological disorders

Module 2 - Professor Mattia Lauriola

Course Contents

-Animal models for cancer therapy
-Modulation of ERBB signaling from tissue homeostasis to cancer progression
-Mechanisms of Resistance to Target Therapy